Receptor utilization by reovirus type 3: distinct binding sites on thymoma and fibroblast cell lines result in differential compartmentalization of virions
Reovirus type 3/D infects cells following binding to specific cell-surface receptors. The
characteristics of these receptors may play an important role in determining post-binding
events critical to the viral life cycle. Some cell lines, ie L-cells, appear to bind reovirus type
3/D utilizing sialylated proteins as specific receptors for viral adsorption. Such binding
results in productive infection. Other cell lines, ie R1. 1 thymoma cells, bind reovirus type 3/D
in a sialic acid independent manner which does not result in productive infection. Yet, a …
characteristics of these receptors may play an important role in determining post-binding
events critical to the viral life cycle. Some cell lines, ie L-cells, appear to bind reovirus type
3/D utilizing sialylated proteins as specific receptors for viral adsorption. Such binding
results in productive infection. Other cell lines, ie R1. 1 thymoma cells, bind reovirus type 3/D
in a sialic acid independent manner which does not result in productive infection. Yet, a …