Experimental reovirus type 3-induced murine biliary tract disease
K Parashar, MJ Tarlow, MA McCrae - Journal of pediatric surgery, 1992 - Elsevier
The aims of this experiment were:(1) to establish a reovirus type 3-induced murine model of
biliary atresia/neonatal hepatitis that as far as possible corresponds to the human
disease;(2) to demonstrate that the disease is histologically similar to the human disease,
and to investigate the natural history of reovirus type 3 infection in this model;(3) to study the
host-virus interrelationships at a molecular level; and (4) to develop sensitive assays that
could be translated to the human disease. In this study we were unable to produce an exact …
biliary atresia/neonatal hepatitis that as far as possible corresponds to the human
disease;(2) to demonstrate that the disease is histologically similar to the human disease,
and to investigate the natural history of reovirus type 3 infection in this model;(3) to study the
host-virus interrelationships at a molecular level; and (4) to develop sensitive assays that
could be translated to the human disease. In this study we were unable to produce an exact …