[HTML][HTML] Sonic Hedgehog-induced activation of the Gli1Promoter is mediated by GLI3
P Dai, H Akimaru, Y Tanaka, T Maekawa… - Journal of Biological …, 1999 - ASBMB
Drosophila transcription factorcubitus interruptus (Ci) and its co-activator CRE (cAMP
response element)-binding protein (CBP) activate a group of target genes on the anterior-
posterior border in response to hedgehog protein (Hh) signaling. In the anterior region, in
contrast, the carboxyl-truncated form of Ci generated by protein processing represses Hh
expression. In vertebrates, three Ci-related transcription factors (glioblastoma gene products
(GLIs) 1, 2, and 3) were identified, but their functional difference in Hh signal transduction is …
response element)-binding protein (CBP) activate a group of target genes on the anterior-
posterior border in response to hedgehog protein (Hh) signaling. In the anterior region, in
contrast, the carboxyl-truncated form of Ci generated by protein processing represses Hh
expression. In vertebrates, three Ci-related transcription factors (glioblastoma gene products
(GLIs) 1, 2, and 3) were identified, but their functional difference in Hh signal transduction is …