[HTML][HTML] Molecular basis defining human Chlamydia trachomatis tissue tropism: a possible role for tryptophan synthase
C Fehlner-Gardiner, C Roshick, JH Carlson… - Journal of Biological …, 2002 - ASBMB
Here we report the cloning and sequencing of a region of the chlamydiae chromosome
termed the" plasticity zone" from all the human serovars of C. trachomatis containing the
tryptophan biosynthesis genes. Our results show that this region contains orthologues of the
tryptophan repressor as well as the α and β subunits of tryptophan synthase. Results from
reverse transcription-PCR and Western blot analyses indicate that the trpBA genes are
transcribed, and protein products are expressed. The TrpB sequences from all serovars are …
termed the" plasticity zone" from all the human serovars of C. trachomatis containing the
tryptophan biosynthesis genes. Our results show that this region contains orthologues of the
tryptophan repressor as well as the α and β subunits of tryptophan synthase. Results from
reverse transcription-PCR and Western blot analyses indicate that the trpBA genes are
transcribed, and protein products are expressed. The TrpB sequences from all serovars are …