T-cell repertoires in healthy and diseased human tissues analysed by T-cell receptor β-chain CDR3 size determination: evidence for oligoclonal expansions in …
J Even, A Lim, I Puisieux, L Ferradini, PY Dietrich… - Research in …, 1995 - Elsevier
Many examples of oligoclonal T-cell expansion in infiltrated diseased tissues have been
reported. However, it remains to be established whether such observations can be
generalized and to what extent oligoclonal patterns obtained after in vitro culture of T-cell
infiltrates reflect in vivo situations. Using new high resolution analysis which requires no in
vitro cellular expansion, we detected such oligoclonal T-cell expansions in 7/7 melanoma
tumour biopsies, 3/3 biopsies of inflammatory skin during acute graft versus host disease …
reported. However, it remains to be established whether such observations can be
generalized and to what extent oligoclonal patterns obtained after in vitro culture of T-cell
infiltrates reflect in vivo situations. Using new high resolution analysis which requires no in
vitro cellular expansion, we detected such oligoclonal T-cell expansions in 7/7 melanoma
tumour biopsies, 3/3 biopsies of inflammatory skin during acute graft versus host disease …