Colloidal aggregates of insoluble inclusions in human goiters

H Gerber, HJ Peter, E Bürgi, S Bigler, J Kaempf… - Biochimie, 1999 - Elsevier
To shed some light on the physicochemical properties of the thyroid follicular colloid, we
have screened retrospectively the autoradiographs of 60 human nodular goiters labeled 17
h preoperatively with 100 μCi 125I for evidence of colloid compartmentalization. In
87%(52/60) of all goiters examined, sporadic or multiple colloidal inclusions (colloid stones')
not mixing with newly labeled Tg were detected. The detailed analysis of 17 goiters revealed
a mean incidence of 0.09±0.11colloid stones' of variable size per follicle ranging from …