[HTML][HTML] The prosegments of furin and PC7 as potent inhibitors of proprotein convertases: in vitro and ex vivo assessment of their efficacy and selectivity
M Zhong, JS Munzer, A Basak, S Benjannet… - Journal of Biological …, 1999 - ASBMB
All proprotein convertases (PCs) of the subtilisin/kexin family contain an N-terminal
prosegment that is presumed to act both as an intramolecular chaperone and an inhibitor of
its parent enzyme. In this work, we examined inhibition by purified, recombinant bacterial
prosegments of furin and PC7 on the in vitro processing of either the fluorogenic peptide
pERTKR-MCA or the human immunodeficiency virus envelope glycoprotein gp160. These
propeptides are potent inhibitors that display measurable selectivity toward specific …
prosegment that is presumed to act both as an intramolecular chaperone and an inhibitor of
its parent enzyme. In this work, we examined inhibition by purified, recombinant bacterial
prosegments of furin and PC7 on the in vitro processing of either the fluorogenic peptide
pERTKR-MCA or the human immunodeficiency virus envelope glycoprotein gp160. These
propeptides are potent inhibitors that display measurable selectivity toward specific …