[HTML][HTML] A novel serum protein similar to C1q, produced exclusively in adipocytes

PE Scherer, S Williams, M Fogliano, G Baldini… - Journal of Biological …, 1995 - ASBMB
We describe a novel 30-kDa secretory protein, Acrp30 (adipocyte complement-related
protein of 30 kDa), that is made exclusively in adipocytes and whose mRNA is induced over
100-fold during adipocyte differentiation. Acrp30 is structurally similar to complement factor
C1q and to a hibernation-specific protein isolated from the plasma of Siberian chipmunks; it
forms large homo-oligomers that undergo a series of post-translational modifications. Like
adipsin, secretion of Acrp30 is enhanced by insulin, and Acrp30 is an abundant serum …