Immunological function of HLA-C antigens in HLA-Cw3 transgenic mice.
O Dill, F Kievits, S KoCH, P Ivanyi… - Proceedings of the …, 1988 - National Acad Sciences
O Dill, F Kievits, S KoCH, P Ivanyi, GJ Hämmerling
Proceedings of the National Academy of Sciences, 1988•National Acad SciencesThe human major histocompatibility complex encodes three classical class I antigens, HLA-
A,-B, and-C. Of these HLA-A and-B act as strong transplantation antigens and as restriction
molecules for recognition of foreign antigen by cytotoxic T lymphocytes. In contrast, little is
known about HLA-C and it is not clear whether HLA-C has the same functional properties as
HLA-A and-B. Transgenic C57BL/6 mice expressing the HLA-Cw3 gene were established.
Functional studies demonstrated that transgenic skin was rapidly rejected by normal …
A,-B, and-C. Of these HLA-A and-B act as strong transplantation antigens and as restriction
molecules for recognition of foreign antigen by cytotoxic T lymphocytes. In contrast, little is
known about HLA-C and it is not clear whether HLA-C has the same functional properties as
HLA-A and-B. Transgenic C57BL/6 mice expressing the HLA-Cw3 gene were established.
Functional studies demonstrated that transgenic skin was rapidly rejected by normal …
The human major histocompatibility complex encodes three classical class I antigens, HLA-A, -B, and -C. Of these HLA-A and -B act as strong transplantation antigens and as restriction molecules for recognition of foreign antigen by cytotoxic T lymphocytes. In contrast, little is known about HLA-C and it is not clear whether HLA-C has the same functional properties as HLA-A and -B. Transgenic C57BL/6 mice expressing the HLA-Cw3 gene were established. Functional studies demonstrated that transgenic skin was rapidly rejected by normal C57BL/6 mice and that cytotoxic T lymphocytes generated by immunization of the Cw3 transgenic mice with influenza and Sendai virus were restricted by the Cw3 molecule. These data suggest that HLA-Cw3 has immunological functions comparable to those of HLA-A and -B.
National Acad Sciences