[HTML][HTML] Regulation of Bad phosphorylation and association with Bcl-xL by the MAPK/Erk kinase

MP Scheid, KM Schubert, V Duronio - Journal of Biological Chemistry, 1999 - ASBMB
Phosphorylation of the Bcl-2 family protein Bad may represent an important bridge between
survival signaling by growth factor receptors and the prevention of apoptosis. Bad
phosphorylation was examined following cytokine stimulation, which revealed
phosphorylation on a critical residue, serine 112, in a MEK-dependent manner. Furthermore,
Bad phosphorylation also increased on several sites distinct from serine 112 but could not
be detected on serine 136, previously thought to be a protein kinase B/Akt-targeted residue …