[HTML][HTML] Mechanisms of estrogen receptor action in the myocardium: rapid gene activation via the ERK1/2 pathway and serum response elements
T De Jager, T Pelzer, S Müller-Botz, A Imam… - Journal of Biological …, 2001 - ASBMB
We have previously shown that the myocardium is a target tissue for estrogen. Here, we
have identified rapid non-nuclear estrogen effects on the expression of the early growth
response gene-1 (Egr-1) in cardiomyocytes. Egr-1mRNA and protein were rapidly and
strongly induced by estrogen in an estrogen receptor-dependent manner via the
extracellular signal-regulated kinase, ERK1/2. A promoter analysis study of a 1.2-kilobase
Egr-1 promoter fragment revealed that the serum response elements (SREs) but not the …
have identified rapid non-nuclear estrogen effects on the expression of the early growth
response gene-1 (Egr-1) in cardiomyocytes. Egr-1mRNA and protein were rapidly and
strongly induced by estrogen in an estrogen receptor-dependent manner via the
extracellular signal-regulated kinase, ERK1/2. A promoter analysis study of a 1.2-kilobase
Egr-1 promoter fragment revealed that the serum response elements (SREs) but not the …