[HTML][HTML] Integrin engagement, the actin cytoskeleton, and c-Src are required for the calcitonin-induced tyrosine phosphorylation of paxillin and HEF1, but not for …
Z Zhang, R Baron, WC Horne - Journal of Biological Chemistry, 2000 - ASBMB
We have previously shown that in a HEK-293 cell line that overexpresses the C1a isoform of
the calcitonin receptor (C1a-HEK), calcitonin induces the tyrosine phosphorylation of the
focal adhesion-associated proteins HEF1 (a p130 Cas-like docking protein), paxillin, and
focal adhesion kinase and that it also stimulates the phosphorylation and activation of Erk1
and Erk2. We report here that cell attachment to the extracellular matrix, an intact actin
cytoskeleton, and c-Src are absolutely required for the calcitonin-induced phosphorylation of …
the calcitonin receptor (C1a-HEK), calcitonin induces the tyrosine phosphorylation of the
focal adhesion-associated proteins HEF1 (a p130 Cas-like docking protein), paxillin, and
focal adhesion kinase and that it also stimulates the phosphorylation and activation of Erk1
and Erk2. We report here that cell attachment to the extracellular matrix, an intact actin
cytoskeleton, and c-Src are absolutely required for the calcitonin-induced phosphorylation of …