Differential Sensitivities of Chlamydia trachomatis Strains to Inhibitory Effects of Gamma Interferon
RP Morrison - Infection and immunity, 2000 - Am Soc Microbiol
RP Morrison
Infection and immunity, 2000•Am Soc MicrobiolGamma interferon (IFN-γ) is an important cytokine in host defense against chlamydial
infection. An in vitro cell culture system was used to show that IFN-γ inhibition of chlamydial
growth, as determined by diminished recovery of infectious elementary bodies, differed
markedly among chlamydial strains. These differences in sensitivity among chlamydial
strains to IFN-γ-mediated inhibition may profoundly influence the clinical outcome of
infection.
infection. An in vitro cell culture system was used to show that IFN-γ inhibition of chlamydial
growth, as determined by diminished recovery of infectious elementary bodies, differed
markedly among chlamydial strains. These differences in sensitivity among chlamydial
strains to IFN-γ-mediated inhibition may profoundly influence the clinical outcome of
infection.
Abstract
Gamma interferon (IFN-γ) is an important cytokine in host defense against chlamydial infection. An in vitro cell culture system was used to show that IFN-γ inhibition of chlamydial growth, as determined by diminished recovery of infectious elementary bodies, differed markedly among chlamydial strains. These differences in sensitivity among chlamydial strains to IFN-γ-mediated inhibition may profoundly influence the clinical outcome of infection.
American Society for Microbiology