[HTML][HTML] Quaternary structure of coronavirus spikes in complex with carcinoembryonic antigen-related cell adhesion molecule cellular receptors
DN Lewicki, TM Gallagher - Journal of biological chemistry, 2002 - ASBMB
Oligomeric spike (S) glycoproteins extend from coronavirus membranes. These integral
membrane proteins assemble within the endoplasmic reticulum of infected cells and are
subsequently endoproteolyzed in the Golgi, generating noncovalently associated S1 and S2
fragments. Once on the surface of infected cells and virions, peripheral S1 fragments bind
carcinoembryonic antigen-related cell adhesion molecule (CEACAM) receptors, and this
triggers membrane fusion reactions mediated by integral membrane S2 fragments. We …
membrane proteins assemble within the endoplasmic reticulum of infected cells and are
subsequently endoproteolyzed in the Golgi, generating noncovalently associated S1 and S2
fragments. Once on the surface of infected cells and virions, peripheral S1 fragments bind
carcinoembryonic antigen-related cell adhesion molecule (CEACAM) receptors, and this
triggers membrane fusion reactions mediated by integral membrane S2 fragments. We …