Mucosal and systemic isotype-specific antibody responses and protection in conventional pigs exposed to virulent or attenuated porcine epidemic diarrhoea virus
ML De Arriba, A Carvajal, J Pozo, P Rubio - Veterinary immunology and …, 2002 - Elsevier
Eleven-day-old conventionally reared piglets were inoculated orally with two different doses
of the cell-culture adapted strain CV-777 of the porcine epidemic diarrhoea virus (PEDV) or
the virulent isolate of the same strain and challenged with the same virulent PEDV 3 weeks
later. Pigs inoculated with the two doses of the attenuated virus did not show any typical sign
of the disease, and virus shedding was not frequent. In contrast, 31% of pigs exposed to the
virulent PEDV developed diarrhoea and virus shedding was demonstrated in 100%. At …
of the cell-culture adapted strain CV-777 of the porcine epidemic diarrhoea virus (PEDV) or
the virulent isolate of the same strain and challenged with the same virulent PEDV 3 weeks
later. Pigs inoculated with the two doses of the attenuated virus did not show any typical sign
of the disease, and virus shedding was not frequent. In contrast, 31% of pigs exposed to the
virulent PEDV developed diarrhoea and virus shedding was demonstrated in 100%. At …