[HTML][HTML] Hypercholesterolemia promotes a CD36-dependent and endothelial nitric-oxide synthase-mediated vascular dysfunction
JF Kincer, A Uittenbogaard, J Dressman… - Journal of Biological …, 2002 - ASBMB
Numerous studies have implicated either the presence or absence of CD36 in the
development of hypertension. In addition, hypercholesterolemia is associated with the loss
of nitric oxide-induced vasodilation and the subsequent increase in blood pressure. In the
current study, we tested the hypothesis that diet-induced hypercholesterolemia promotes the
disruption of agonist-stimulated nitric oxide generation and vasodilation in a CD36-
dependent manner. To test this, C57BL/6, apoE null, CD36 null, and apoE/CD36 null mice …
development of hypertension. In addition, hypercholesterolemia is associated with the loss
of nitric oxide-induced vasodilation and the subsequent increase in blood pressure. In the
current study, we tested the hypothesis that diet-induced hypercholesterolemia promotes the
disruption of agonist-stimulated nitric oxide generation and vasodilation in a CD36-
dependent manner. To test this, C57BL/6, apoE null, CD36 null, and apoE/CD36 null mice …