A subset of memory CD4+ helper T lymphocytes identified by expression of Pgp-1.
K Butterfield, CG Fathman, RC Budd - The Journal of experimental …, 1989 - rupress.org
K Butterfield, CG Fathman, RC Budd
The Journal of experimental medicine, 1989•rupress.orgThe Pgp-1 glycoprotein (Ly-24 antigen) is acquired by mature murine T lymphocytes at the
time of primary antigen stimulation Pgp-1 was previously shown to be a useful cell surface
marker for distinguishing antigen-specific memory CD8+ T lymphocytes after immunization.
Here we demonstrate that this observation extends to CD4+ T lymphocytes. Antigen-specific
CD4+ T cells in mice immunized with sperm whale myoglobin or keyhole limpet hemocyanin
were contained nearly exclusively in the minor Pgp-1+ subset.
time of primary antigen stimulation Pgp-1 was previously shown to be a useful cell surface
marker for distinguishing antigen-specific memory CD8+ T lymphocytes after immunization.
Here we demonstrate that this observation extends to CD4+ T lymphocytes. Antigen-specific
CD4+ T cells in mice immunized with sperm whale myoglobin or keyhole limpet hemocyanin
were contained nearly exclusively in the minor Pgp-1+ subset.
The Pgp-1 glycoprotein (Ly-24 antigen) is acquired by mature murine T lymphocytes at the time of primary antigen stimulation Pgp-1 was previously shown to be a useful cell surface marker for distinguishing antigen-specific memory CD8+ T lymphocytes after immunization. Here we demonstrate that this observation extends to CD4+ T lymphocytes. Antigen-specific CD4+ T cells in mice immunized with sperm whale myoglobin or keyhole limpet hemocyanin were contained nearly exclusively in the minor Pgp-1+ subset.
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