Immunohistochemical analysis of platelet-derived growth factor-B expression in myocardial tissues in hypertrophic cardiomyopathy

J Suzuki, S Baba, I Ohno, M Endoh, J Nawata… - Cardiovascular …, 1999 - Elsevier
Intimal and/or medial hyperplasia of intramyocardial small vessels is thought to be one of the
causes of myocardial ischemia in hypertrophic cardiomyopathy (HCM). However, the
pathogenesis of such vascular lesions in HCM is not yet known. To evaluate the pathogenic
role of platelet-derived growth factor (PDGF-B) and basic fibroblast growth factor (b-FGF),
which have a potential to induce cellular and molecular changes observed in the vessels in
HCM, we examined the expression of these molecules and PDGF receptors in cardiac …