[HTML][HTML] Hypoxia-inducible factor-2α (HIF-2α) is involved in the apoptotic response to hypoglycemia but not to hypoxia
Deprivation of oxygen (hypoxia) and/or glucose (hypoglycemia) represents a serious stress
that affects cellular survival. The hypoxia-inducible transcription factor-1α (HIF-1α), which
has been implicated in the cellular response to hypoxia (Semenza, GL (1999) Annu. Rev.
Cell Dev. Biol. 15, 551–578), mediates apoptosis during hypoxia (Halterman, MW, Miller,
CC, and Federoff, HJ (1999) J. Neurosci. 19, 6818–6824 and Carmeliet, P., Dor, Y., Herbert,
JM, Fukumura, D., Brusselmans, K., Dewerchin, M., Neeman, M., Bono, F., Abramovitch, R …
that affects cellular survival. The hypoxia-inducible transcription factor-1α (HIF-1α), which
has been implicated in the cellular response to hypoxia (Semenza, GL (1999) Annu. Rev.
Cell Dev. Biol. 15, 551–578), mediates apoptosis during hypoxia (Halterman, MW, Miller,
CC, and Federoff, HJ (1999) J. Neurosci. 19, 6818–6824 and Carmeliet, P., Dor, Y., Herbert,
JM, Fukumura, D., Brusselmans, K., Dewerchin, M., Neeman, M., Bono, F., Abramovitch, R …