[HTML][HTML] A role for the p38 MAP kinase pathway in the nuclear shuttling of NFATp
PG del Arco, S Martı́nez-Martı́nez, JL Maldonado… - Journal of Biological …, 2000 - ASBMB
Calcium signals lead to the translocation of nuclear factor of activated T cells (NFAT) from
the cytoplasm to the nucleus. This process is regulated by the calcium-activated
phosphatase calcineurin, which can be cotransported with NFAT to the nucleus to maintain it
transcriptionally active for the duration of calcium signaling. When the calcium signal
ceases, NFAT is exported to the cytoplasm, and different NFAT kinases have been reported
to oppose calcineurin activities and regulate the nuclear export of NFAT. Here we show that …
the cytoplasm to the nucleus. This process is regulated by the calcium-activated
phosphatase calcineurin, which can be cotransported with NFAT to the nucleus to maintain it
transcriptionally active for the duration of calcium signaling. When the calcium signal
ceases, NFAT is exported to the cytoplasm, and different NFAT kinases have been reported
to oppose calcineurin activities and regulate the nuclear export of NFAT. Here we show that …