[HTML][HTML] Bid is cleaved by calpain to an active fragment in vitro and during myocardial ischemia/reperfusion
M Chen, H He, S Zhan, S Krajewski, JC Reed… - Journal of Biological …, 2001 - ASBMB
Reperfusion after myocardial ischemia is associated with a rapid influx of calcium, leading to
activation of various enzymes including calpain. Isolated perfused adult rabbit hearts
subjected to global ischemia and reperfusion were studied. Calpain or a calpain-like activity
was activated within 15 min after reperfusion, and preconditioning suppressed calpain
activation. In contrast, caspase activation was not detected although cytochromec was
released after ischemia and reperfusion. The pro-apoptotic BH3-only Bcl-2 family member …
activation of various enzymes including calpain. Isolated perfused adult rabbit hearts
subjected to global ischemia and reperfusion were studied. Calpain or a calpain-like activity
was activated within 15 min after reperfusion, and preconditioning suppressed calpain
activation. In contrast, caspase activation was not detected although cytochromec was
released after ischemia and reperfusion. The pro-apoptotic BH3-only Bcl-2 family member …