Phosphorylation and dephosphorylation of glycogen phosphorylase: a prototype for reversible covalent enzyme modification
EG KREBS - Current topics in cellular regulation, 1981 - Elsevier
In the early 1940s the Coris and their associates discovered that glycogen phosphorylase, a
rate-limiting enzyme in the breakdown of glycogen, exists in two interconvertible forms that
they designated as phosphorylases a and b (1). An enzyme was found that would convert
phosphorylase a to phosphorylase b in vitro, and, although the chemical nature of the
reaction being catalyzed was unknown, it was recognized that phosphorylase was being
modified covalently (1, 2). The total phosphorus content of phosphorylase a was shown to …
rate-limiting enzyme in the breakdown of glycogen, exists in two interconvertible forms that
they designated as phosphorylases a and b (1). An enzyme was found that would convert
phosphorylase a to phosphorylase b in vitro, and, although the chemical nature of the
reaction being catalyzed was unknown, it was recognized that phosphorylase was being
modified covalently (1, 2). The total phosphorus content of phosphorylase a was shown to …