Effect of morphine on lipopolysaccharide-induced tumor necrosis factor-α production in vivo: involvement of the sympathetic nervous system
A Bencsics, IJ Elenkov, ES Vizi - Journal of neuroimmunology, 1997 - Elsevier
Morphine treatment modulates a variety of immunological parameters, including tumor
necrosis factor-α (TNF-α) production by activated macrophages in vitro. The aim of our study
was to clarify the effect of morphine on lipopolysaccharide (LPS)-induced TNF-α production
in vivo. Plasma TNF-α levels of mice were determined by ELISA. Subcutaneous injection of
morphine decreased LPS-induced TNF-α production throughout the response, an effect that
was dose-dependent and reversible by naloxone. Blockade of the sympathetic transmission …
necrosis factor-α (TNF-α) production by activated macrophages in vitro. The aim of our study
was to clarify the effect of morphine on lipopolysaccharide (LPS)-induced TNF-α production
in vivo. Plasma TNF-α levels of mice were determined by ELISA. Subcutaneous injection of
morphine decreased LPS-induced TNF-α production throughout the response, an effect that
was dose-dependent and reversible by naloxone. Blockade of the sympathetic transmission …