mecA-blaZ Corepressors in Clinical Staphylococcus aureus Isolates
AE Rosato, BN Kreiswirth, WA Craig… - Antimicrobial agents …, 2003 - Am Soc Microbiol
AE Rosato, BN Kreiswirth, WA Craig, W Eisner, MW Climo, GL Archer
Antimicrobial agents and chemotherapy, 2003•Am Soc MicrobiolThe presence and nucleotide sequences of the two mecA repressors, mecI and blaI, were
assessed in 73 clinical Staphylococcus aureus isolates. Isolates with mecI mutations were
grouped into unique clonal types based on their spa nucleotide repeat patterns. Forty-three
of the 45 (96%) isolates with mutant mecI or with a deletion of mecI contained blaI, while blaI
was present in only 21 of 28 (78%) isolates with wild-type mecI (P< 0.05). Among 22
additional isolates that did not contain blaI, all had wild-type mecI sequences. We conclude …
assessed in 73 clinical Staphylococcus aureus isolates. Isolates with mecI mutations were
grouped into unique clonal types based on their spa nucleotide repeat patterns. Forty-three
of the 45 (96%) isolates with mutant mecI or with a deletion of mecI contained blaI, while blaI
was present in only 21 of 28 (78%) isolates with wild-type mecI (P< 0.05). Among 22
additional isolates that did not contain blaI, all had wild-type mecI sequences. We conclude …
Abstract
The presence and nucleotide sequences of the two mecA repressors, mecI and blaI, were assessed in 73 clinical Staphylococcus aureus isolates. Isolates with mecI mutations were grouped into unique clonal types based on their spa nucleotide repeat patterns. Forty-three of the 45 (96%) isolates with mutant mecI or with a deletion of mecI contained blaI, while blaI was present in only 21 of 28 (78%) isolates with wild-type mecI (P < 0.05). Among 22 additional isolates that did not contain blaI, all had wild-type mecI sequences. We conclude that oxacillin-resistant S. aureus must have at least one of the two functional mecA regulators.
American Society for Microbiology