Molecular structures of penicillin-binding proteins and β-lactamases
JM Ghuysen - Trends in microbiology, 1994 - cell.com
JM Ghuysen
Trends in microbiology, 1994•cell.comT he most familiar anti-bacterial agents, the penicillins, exert their effects by interacting with a
class of enzymes, the penicillin-binding proteins (PBPs), that is responsible for the
polymerization of precursor disaccharidepentapeptide molecules to form the cell-wall
peptidoglycan (Fig. 1). Resistance to penicillins, which are p-lactams, is most commonly due
to the presence of p-lactamases(see p. 421 for a glossary of anti-
class of enzymes, the penicillin-binding proteins (PBPs), that is responsible for the
polymerization of precursor disaccharidepentapeptide molecules to form the cell-wall
peptidoglycan (Fig. 1). Resistance to penicillins, which are p-lactams, is most commonly due
to the presence of p-lactamases(see p. 421 for a glossary of anti-
T he most familiar anti-bacterial agents, the penicillins, exert their effects by interacting with a class of enzymes, the penicillin-binding proteins (PBPs), that is responsible for the polymerization of precursor disaccharidepentapeptide molecules to form the cell-wall peptidoglycan (Fig. 1). Resistance to penicillins, which are p-lactams, is most commonly due to the presence of p-lactamases(see p. 421 for a glossary of anti-
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