Methicillin resistance in Staphylococcus aureus

MT Parker, JH Hewitt - The Lancet, 1970 - Elsevier
Two independent surveys of the frequency of methicillin resistance in Staphylococcus
aureus indicate that there was a moderate increase between 1960 and 1963, followed by a
stationary period. A second increase began in 1968 and is continuing. Resistant strains
have been present in many hospitals for some years, and the more recent increase in
frequency seems to be due to their wider dissemination among the patients. The spread of
methicillin-resistant staphylococci is probably encouraged by the use of all penicillins and …

A survey of methicillin resistance in Staphylococcus aureus

MT Parker, MP Jevons - Postgraduate medical journal, 1964 - ncbi.nlm.nih.gov
IN an earlier symposium on the resistance of bacteria to the penicillins, Barber (1962)
emphasized the difficulties of obtaining an estimate of the incidence of methicillin resistance
in Staphylococcus aureus. To yield re-liable information, the population under investigation
must be large and diverse, and must be sampled in a uniform way; and the degree of
resistance to be recorded must be defined precisely. In the survey we began in 1960 we
have tried to fulfil these criteria. During the last three and a half years we have carried out …

The Detection Of Methicillin Resistance In Staphylococcus Aureus

JH Hewitt, AW Coe, MT Parker - Journal of Medical …, 1969 - microbiologyresearch.org
Some methicillin-resistant cultures of Staphylococcus aureus give equivocal results when
tested in disk diffusion tests or tube dilution MIC tests incubated at 37° C. Practically all
resistant cultures have the following characters:(1) they give growth up to or to within 1 mm
of a 10 μg methicillin disk in a disk diffusion test on nutrient agar or blood agar incubated at
30° C, and (2) they show a MIC of 25 μg methicillin per ml or greater after incubation for 18
hr at 30° C, or for 48 hr at 37° C, in a tube dilution test in nutrient broth. Tests for growth at …