Mice deficient in fractalkine are less susceptible to cerebral ischemia-reperfusion injury
SG Soriano, LS Amaravadi, YF Wang, H Zhou… - Journal of …, 2002 - Elsevier
Fractalkine (FKN), also known as neurotactin, is a CX3C chemokine that exists in both
secreted and neuronal membrane-bound forms and is upregulated during brain
inflammation. There is accumulating evidence that FKN induces chemotaxis by binding to its
receptor CX3CR1 on leukocytes and microglia. We generated FKN-deficient mice to study
the role of FKN in postischemic brain injury. After transient focal cerebral ischemia, FKN-
deficient mice had a 28% reduction in infarction size and lower mortality rate, when …
secreted and neuronal membrane-bound forms and is upregulated during brain
inflammation. There is accumulating evidence that FKN induces chemotaxis by binding to its
receptor CX3CR1 on leukocytes and microglia. We generated FKN-deficient mice to study
the role of FKN in postischemic brain injury. After transient focal cerebral ischemia, FKN-
deficient mice had a 28% reduction in infarction size and lower mortality rate, when …