[HTML][HTML] Identification of CX 3CR1: A CHEMOTACTIC RECEPTOR FOR THE HUMAN CX 3C CHEMOKINE FRACTALKINE AND A FUSION CORECEPTOR FOR HIV-1
C Combadiere, K Salzwedel, ED Smith… - Journal of Biological …, 1998 - ASBMB
Fractalkine is a multimodular human leukocyte chemoattractant protein and a member of the
chemokine superfamily. Unlike other human chemokines, the chemokine domain of
fractalkine has three amino acids between two conserved cysteines, referred to as the CX 3
C motif. Both plasma membrane-associated and shed forms of fractalkine have been
identified. Here, we show that the recombinant 76-amino acid chemokine domain of
fractalkine is a potent and highly specific chemotactic agonist at a human orphan receptor …
chemokine superfamily. Unlike other human chemokines, the chemokine domain of
fractalkine has three amino acids between two conserved cysteines, referred to as the CX 3
C motif. Both plasma membrane-associated and shed forms of fractalkine have been
identified. Here, we show that the recombinant 76-amino acid chemokine domain of
fractalkine is a potent and highly specific chemotactic agonist at a human orphan receptor …