[HTML][HTML] Tumor necrosis factor-α-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1)
KJ Garton, PJ Gough, CP Blobel, G Murphy… - Journal of Biological …, 2001 - ASBMB
Fractalkine (CX3CL1) is an unusual member of the chemokine family that is synthesized
with its chemokine domain at the end of a mucin-rich, transmembrane stalk. This membrane-
bound localization allows fractalkine to function as an adhesion molecule for cells bearing
its receptor, CX3CR1. In addition, fractalkine can be proteolytically released from the cell
surface, generating a soluble molecule that functions as a chemoattractant similar to the
other members of the chemokine family. In this study, we have examined the mechanisms …
with its chemokine domain at the end of a mucin-rich, transmembrane stalk. This membrane-
bound localization allows fractalkine to function as an adhesion molecule for cells bearing
its receptor, CX3CR1. In addition, fractalkine can be proteolytically released from the cell
surface, generating a soluble molecule that functions as a chemoattractant similar to the
other members of the chemokine family. In this study, we have examined the mechanisms …