Anti-CD40, anti-CD3, and IL-2 stimulation induce contrasting changes in CB1 mRNA expression in mouse splenocytes
SN Noe, C Newton, R Widen, H Friedman… - Journal of …, 2000 - Elsevier
The expression and function of cannabinoid receptor 1 (CB1) in mouse immune cells is
unclear. Here we show that splenic B cells express more CB1 mRNA than T cells.
Furthermore, splenocytes stimulated with the T cell mitogens, PMA/Io and anti-CD3, showed
a decrease in CB1 message while cultures stimulated with the B cell mitogen, anti-CD40
antibody, showed an increase in message. In addition, co-treatment with mitogens and IL-2
uniformly caused an increase in CB1 mRNA. It is suggested that signaling pathways …
unclear. Here we show that splenic B cells express more CB1 mRNA than T cells.
Furthermore, splenocytes stimulated with the T cell mitogens, PMA/Io and anti-CD3, showed
a decrease in CB1 message while cultures stimulated with the B cell mitogen, anti-CD40
antibody, showed an increase in message. In addition, co-treatment with mitogens and IL-2
uniformly caused an increase in CB1 mRNA. It is suggested that signaling pathways …