[HTML][HTML] Heparan sulfate proteoglycan isoforms of the CD44 hyaluronan receptor induced in human inflammatory macrophages can function as paracrine regulators of …
M Jones, L Tussey, N Athanasou… - Journal of Biological …, 2000 - ASBMB
The CD44 glycoprotein is expressed in multiple isoforms on a variety of cell types where it
functions as a receptor for hyaluronan-mediated motility. Recently, interest has centered on
CD44 heparan sulfate proteoglycan (HSPG) isoforms because of their potential to sequester
heparin-binding growth factors and chemokines. Expression of these isoforms on
ectodermal cells has recently been shown to regulate limb morphogenesis via presentation
of fibroblast growth factor (FGF) 4/FGF 8 while expression on tumor cells was shown to …
functions as a receptor for hyaluronan-mediated motility. Recently, interest has centered on
CD44 heparan sulfate proteoglycan (HSPG) isoforms because of their potential to sequester
heparin-binding growth factors and chemokines. Expression of these isoforms on
ectodermal cells has recently been shown to regulate limb morphogenesis via presentation
of fibroblast growth factor (FGF) 4/FGF 8 while expression on tumor cells was shown to …