Spontaneous retinopathy in HLA-A29 transgenic mice
Y Szpak, JC Vieville, T Tabary… - Proceedings of the …, 2001 - National Acad Sciences
Y Szpak, JC Vieville, T Tabary, MC Naud, M Chopin, C Edelson, JHM Cohen, J Dausset…
Proceedings of the National Academy of Sciences, 2001•National Acad SciencesHumans who have inherited the class I major histocompatibility allele HLA-A29 have a
markedly increased relative risk of developing the eye disease termed birdshot
chorioretinopathy. This disease affecting adults is characterized by symmetrically scattered,
small, cream-colored spots in the fundus associated with retinal vasculopathy and
inflammatory signs causing damage to the ocular structures, leading regularly to visual loss.
To investigate the role of HLA-A29 in this disease, we introduced the HLA-A29 gene into …
markedly increased relative risk of developing the eye disease termed birdshot
chorioretinopathy. This disease affecting adults is characterized by symmetrically scattered,
small, cream-colored spots in the fundus associated with retinal vasculopathy and
inflammatory signs causing damage to the ocular structures, leading regularly to visual loss.
To investigate the role of HLA-A29 in this disease, we introduced the HLA-A29 gene into …
Humans who have inherited the class I major histocompatibility allele HLA-A29 have a markedly increased relative risk of developing the eye disease termed birdshot chorioretinopathy. This disease affecting adults is characterized by symmetrically scattered, small, cream-colored spots in the fundus associated with retinal vasculopathy and inflammatory signs causing damage to the ocular structures, leading regularly to visual loss. To investigate the role of HLA-A29 in this disease, we introduced the HLA-A29 gene into mice. Aging HLA-A29 transgenic mice spontaneously developed retinopathy, showing a striking resemblance to the HLA-A29-associated chorioretinopathy. These results strongly suggest that HLA-A29 is involved in the pathogenesis of this disease. Elucidation of the role of HLA-A29 should be assisted by this transgenic model.
National Acad Sciences