[HTML][HTML] Glucose stimulates translocation of the homeodomain transcription factor PDX1 from the cytoplasm to the nucleus in pancreatic β-cells
WM Macfarlane, CM McKinnon… - Journal of Biological …, 1999 - ASBMB
One of the mechanisms whereby glucose stimulates insulin gene transcription in pancreatic
β-cells involves activation of the homeodomain transcription factor PDX1
(pancreatic/duodenal homeobox-1) via a stress-activated pathway involving stress-activated
protein kinase 2 (SAPK2, also termed RK/p38, CSBP, and Mxi2). In the present study we
show, by Western blotting and electrophoretic mobility shift assay, that in human islets of
Langerhans incubated in low glucose (3 mm) PDX1 exists as an inactive 31-kDa protein …
β-cells involves activation of the homeodomain transcription factor PDX1
(pancreatic/duodenal homeobox-1) via a stress-activated pathway involving stress-activated
protein kinase 2 (SAPK2, also termed RK/p38, CSBP, and Mxi2). In the present study we
show, by Western blotting and electrophoretic mobility shift assay, that in human islets of
Langerhans incubated in low glucose (3 mm) PDX1 exists as an inactive 31-kDa protein …