[HTML][HTML] Stimulation of osteoprotegerin (OPG) gene expression by transforming growth factor-β (TGF-β): Mapping of the OPG promoter region that mediates TGF-β …
K Thirunavukkarasu, RR Miles, DL Halladay… - Journal of Biological …, 2001 - ASBMB
Transforming growth factor-β (TGF-β) regulates osteoclastogenesis and osteoclast survival,
in part through the induction of osteoprotegerin (OPG), a protein known to inhibit osteoclast
formation and function. To explore the molecular basis of TGF-β regulation of OPG
expression, we evaluated the effects of TGF-β on osteoclast formation, OPG protein
secretion, mRNA expression, and gene transcription. The marked inhibitory effect of TGF-β
on osteoclast differentiation was confirmed in a co-culture model utilizing murine …
in part through the induction of osteoprotegerin (OPG), a protein known to inhibit osteoclast
formation and function. To explore the molecular basis of TGF-β regulation of OPG
expression, we evaluated the effects of TGF-β on osteoclast formation, OPG protein
secretion, mRNA expression, and gene transcription. The marked inhibitory effect of TGF-β
on osteoclast differentiation was confirmed in a co-culture model utilizing murine …