Electrophilic eicosanoids of the J series, with their distinctive cross-conjugated α, β-
unsaturated ketone, inactivate genetically wild type tumor suppressor p53 in a manner
analogous to prostaglandins of the A series. Like the prostaglandins of the A series,
prostaglandins of the J series have a structural determinant (endocyclic cyclopentenone)
that confers the ability to impair the conformation, the phosphorylation, and the
transcriptional activity of the p53 tumor suppressor with equivalent potency and efficacy …