[HTML][HTML] Determinants of 5-lipoxygenase nuclear localization using green fluorescent protein/5-lipoxygenase fusion proteins
XS Chen, YY Zhang, CD Funk - Journal of Biological Chemistry, 1998 - ASBMB
5-Lipoxygenase catalyzes the first two steps in the biosynthesis of leukotrienes, potent
extracellular mediators of inflammation and allergic disorders. The unanticipated
observation of 5-lipoxygenase in the nucleus of some cell types including bone marrow-
derived mast cells (Chen, XS, Naumann, TA, Kurre, U., Jenkins, NA, Copeland, NG, and
Funk, CD (1995) J. Biol. Chem. 270, 17993–17999) has raised speculation about
intranuclear actions of leukotrienes or the enzyme itself. To explore the entry of 5 …
extracellular mediators of inflammation and allergic disorders. The unanticipated
observation of 5-lipoxygenase in the nucleus of some cell types including bone marrow-
derived mast cells (Chen, XS, Naumann, TA, Kurre, U., Jenkins, NA, Copeland, NG, and
Funk, CD (1995) J. Biol. Chem. 270, 17993–17999) has raised speculation about
intranuclear actions of leukotrienes or the enzyme itself. To explore the entry of 5 …