[HTML][HTML] Molecular Basis of the Specific Subcellular Localization of the C2-like Domain of 5-Lipoxygenase∗
The activation of 5-lipoxygenase (5-LO) involves its calcium-dependent translocation to the
nuclear envelope, where it catalyzes the two-step transformation of arachidonic acid into
leukotriene A 4, leading to the synthesis of various leukotrienes. To understand the
mechanism by which 5-LO is specifically targeted to the nuclear envelope, we studied the
membrane binding properties of the amino-terminal domain of 5-LO, which has been
proposed to have a C2 domain-like structure. The model building, electrostatic potential …
nuclear envelope, where it catalyzes the two-step transformation of arachidonic acid into
leukotriene A 4, leading to the synthesis of various leukotrienes. To understand the
mechanism by which 5-LO is specifically targeted to the nuclear envelope, we studied the
membrane binding properties of the amino-terminal domain of 5-LO, which has been
proposed to have a C2 domain-like structure. The model building, electrostatic potential …