[HTML][HTML] Duplicated downstream enhancers control expression of the human apolipoprotein E gene in macrophages and adipose tissue
SJ Shih, C Allan, S Grehan, E Tse, C Moran… - Journal of Biological …, 2000 - ASBMB
Two distal enhancers that specify apolipoprotein (apo) E gene expression in isolated
macrophages and adipose tissue were identified in transgenic mice that were generated
with constructs of the human apoE/CI/CI′/C-IV/C-II gene cluster. One of these enhancers,
multienhancer 1, consists of a 620-nucleotide sequence located 3.3 kilobases (kb)
downstream of the apoE gene. The second enhancer, multienhancer 2, is a 619-nucleotide
sequence located 15.9 kb downstream of the apoE gene and 5.9 kb downstream of the …
macrophages and adipose tissue were identified in transgenic mice that were generated
with constructs of the human apoE/CI/CI′/C-IV/C-II gene cluster. One of these enhancers,
multienhancer 1, consists of a 620-nucleotide sequence located 3.3 kilobases (kb)
downstream of the apoE gene. The second enhancer, multienhancer 2, is a 619-nucleotide
sequence located 15.9 kb downstream of the apoE gene and 5.9 kb downstream of the …