Peripheral fat metabolism during infusion of an exogeneous triacylglycerol emulsion
JS Samra, SL Giles, LKM Summers… - International journal of …, 1998 - nature.com
JS Samra, SL Giles, LKM Summers, RD Evans, P Arner, SM Humphreys, ML Clark…
International journal of obesity, 1998•nature.comOBJECTIVE: To test the hypothesis that intravenous infusion of lipid would bring about
changes in adipose tissue metabolism, which would tend to spare net fat mobilization, and
to attempt to identify the mediators of such responses. DESIGN: The triacylglycerol (TG)
emulsion, Intralipid, was infused and metablic changes in subcutaneous adipose tissue and
forearm muscle were assessed by measurements of arterio-venous differences. SUBJECTS:
Six normal male subjects aged 21–37 y, with body mass index (BMI) 23.0–25.9 kg/m 2 …
changes in adipose tissue metabolism, which would tend to spare net fat mobilization, and
to attempt to identify the mediators of such responses. DESIGN: The triacylglycerol (TG)
emulsion, Intralipid, was infused and metablic changes in subcutaneous adipose tissue and
forearm muscle were assessed by measurements of arterio-venous differences. SUBJECTS:
Six normal male subjects aged 21–37 y, with body mass index (BMI) 23.0–25.9 kg/m 2 …
Abstract
OBJECTIVE: To test the hypothesis that intravenous infusion of lipid would bring about changes in adipose tissue metabolism, which would tend to spare net fat mobilization, and to attempt to identify the mediators of such responses.
DESIGN: The triacylglycerol (TG) emulsion, Intralipid, was infused and metablic changes in subcutaneous adipose tissue and forearm muscle were assessed by measurements of arterio-venous differences.
SUBJECTS: Six normal male subjects aged 21–37 y, with body mass index (BMI) 23.0–25.9 kg/m 2.
RESULTS: Plasma TG and non-esterified fatty acid (NEFA) concentrations rose during infusion as expected. The rise in systemic plasma NEFA concentration occurred despite decreased NEFA release from adipose tissue. Intralipid infusion resulted in a suppression of intracellular lipolysis in adipose tissue, by mechanisms which are not clear. Plasma leptin concentrations, measured in a search for the regulator of lipolysis, showed consistent leptin release from adipose tissue which did not change significantly with time.
CONCLUSION: The suppression of intracellular lipolysis in adipose tissue during Intralipid infusion is a new observation and may reflect a novel mechanism for regulation of fat storage.
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