Cation sensing receptors in bone: a novel paradigm for regulating bone remodeling?

LD Quarles - Journal of Bone and Mineral Research, 1997 - academic.oup.com
Journal of Bone and Mineral Research, 1997academic.oup.com
BONE UNDERGOES a remodeling process consisting of osteoblast-mediated bone
formation coupled to osteoclastic resorption of bone. This regenerative process involves the
coordinated activities of osteoclasts, which are of hematopoietic origin, and osteoblasts,
which are derived from mesenchymal stem cells. These cells, respectively, remove and
replace mineralized bone in a discrete microenvironment on bone surfaces. Hormones,
local and matrix-derived growth factors and cytokines, as well as cell-to-cell interactions …
BONE UNDERGOES a remodeling process consisting of osteoblast-mediated bone formation coupled to osteoclastic resorption of bone. This regenerative process involves the coordinated activities of osteoclasts, which are of hematopoietic origin, and osteoblasts, which are derived from mesenchymal stem cells. These cells, respectively, remove and replace mineralized bone in a discrete microenvironment on bone surfaces. Hormones, local and matrix-derived growth factors and cytokines, as well as cell-to-cell interactions modulate osteoblast and osteoclast function and mediate cross-talk between osteoblasts and osteoclasts. A recent advance in our understanding of bone metabolism is the recognition that calcium released from bone may directly regulate bone cell function and participate in coordinating the activities of osteoblasts and osteoclasts in concert with calcitropic peptides.
Oxford University Press