Frequency of allergen-specific T lymphocytes in blood and bronchial response to allergen in asthma
SE Burastero, D Fenoglio, E Crimi, V Brusasco… - Journal of allergy and …, 1993 - Elsevier
Background: This study was designed to investigate whether the bronchial response to the
sensitizing allergen in asthma is correlated with the frequency of allergen-specific T
lymphocytes. Methods: Twenty-three asthmatic patients sensitized to Dermatophagoides
pteryonyssinus who had never received hyposensitizing therapy and 11 healthy control
subjects were studied. Allergen-specific T lymphocytes were enumerated in peripheral
blood with limiting dilution cultures. Bronchial challenge with methacholine was performed …
sensitizing allergen in asthma is correlated with the frequency of allergen-specific T
lymphocytes. Methods: Twenty-three asthmatic patients sensitized to Dermatophagoides
pteryonyssinus who had never received hyposensitizing therapy and 11 healthy control
subjects were studied. Allergen-specific T lymphocytes were enumerated in peripheral
blood with limiting dilution cultures. Bronchial challenge with methacholine was performed …