Comparison of lymphokine secretion and responsiveness of human T cell clones isolated in IL-4 and in IL-2
X Paliard, JE De Vries, H Spits - Cellular immunology, 1991 - Elsevier
Abstract Interleukin (IL)-4 has been shown to be secreted simultaneously with IL-2 and
interferon (IFN)-γ by the majority of CD4+ human T cell clones isolated and cultured using IL-
2 as a growth factor. Moreover, IL-4 was found to be as efficient as IL-2 to promote the
outgrowth of human T cell clones. In this study we have investigated the pattern of
lymphokine production by human T cell clones isolated and cultured in IL-4. Most of the
CD4+ T cell clones isolated in IL-4 were found to have the ability to simultaneously secrete …
interferon (IFN)-γ by the majority of CD4+ human T cell clones isolated and cultured using IL-
2 as a growth factor. Moreover, IL-4 was found to be as efficient as IL-2 to promote the
outgrowth of human T cell clones. In this study we have investigated the pattern of
lymphokine production by human T cell clones isolated and cultured in IL-4. Most of the
CD4+ T cell clones isolated in IL-4 were found to have the ability to simultaneously secrete …