Allergen-specific human T cell clones: derivation, specificity, and activation requirements
G Gurka, J Ohman Jr, LJ Rosenwasser - Journal of allergy and clinical …, 1989 - Elsevier
The interaction between allergen and immune cells plays a pivotal role in the development
of human allergy. In an attempt to understand this interaction, we have studied allergen-
specific T cells in vitro. These T cells are derived from rodent-allergic individuals and are
specific for a major allergen found in mouse urine (MA-1). Antigen-specific, major
histocompatibility complex-restricted, human T cell clones have been generated by limiting
dilution from lines derived from the peripheral blood T cells of allergic individuals. Antigen …
of human allergy. In an attempt to understand this interaction, we have studied allergen-
specific T cells in vitro. These T cells are derived from rodent-allergic individuals and are
specific for a major allergen found in mouse urine (MA-1). Antigen-specific, major
histocompatibility complex-restricted, human T cell clones have been generated by limiting
dilution from lines derived from the peripheral blood T cells of allergic individuals. Antigen …