High affinity human IgE receptor (Fc epsilon RI). Analysis of functional domains of the alpha-subunit with monoclonal antibodies

F Riske, J Hakimi, M Mallamaci, M Griffin… - Journal of Biological …, 1991 - ASBMB
The binding of IgE to the high affinity Fc epsilon receptor (Fc epsilon RI) on mast cells and
basophils is mediated by the alpha-subunit of the tetrameric receptor complex. Based on
sequence homologies, the 50-kDa alpha-subunit is a member of the immunoglobulin
superfamily of proteins and has two predicted disulfide-bonded loops. Monoclonal
antibodies specific for the human alpha-subunit have been identified and separated into two
major classes: inhibitory and noninhibitory antibodies. Inhibitory antibodies (ie 15A5) block …