[HTML][HTML] Regulation of WNK1 by an autoinhibitory domain and autophosphorylation

B Xu, X Min, S Stippec, BH Lee, EJ Goldsmith… - Journal of Biological …, 2002 - ASBMB
WNK family protein kinases are large enzymes that contain the catalytic lysine in a unique
position compared with all other protein kinases. These enzymes have been linked to a
genetically defined form of hypertension. In this study we introduced mutations to test
hypotheses about the position of the catalytic lysine, and we examined mechanisms
involved in the regulation of WNK1 activity. Through the analysis of enzyme fragments and
sequence alignments, we have identified an autoinhibitory domain of WNK1. This isolated …