Evidence of IgG autoantibodies against human proinsulin in patients with IDDM before insulin treatment
B Kuglin, FA Gries, H Kolb - Diabetes, 1988 - Am Diabetes Assoc
B Kuglin, FA Gries, H Kolb
Diabetes, 1988•Am Diabetes AssocIgG proinsulin autoantibodies (IgG-PAAs) have been found in a fraction of sera from patients
with newly diagnosed insulin-dependent diabetes mellitus (IDDM) before onset of insulin
treatment. Only sera lacking insulin antibodies have been analyzed, to avoid interference.
Competitive inhibition studies provide specificity for human proinsulin but not for insulin. IgG-
PAAs largely cross-react with human C-peptide. Precursors of insulin thus are involved in
the immune process of IDDM.
with newly diagnosed insulin-dependent diabetes mellitus (IDDM) before onset of insulin
treatment. Only sera lacking insulin antibodies have been analyzed, to avoid interference.
Competitive inhibition studies provide specificity for human proinsulin but not for insulin. IgG-
PAAs largely cross-react with human C-peptide. Precursors of insulin thus are involved in
the immune process of IDDM.
IgG proinsulin autoantibodies (IgG-PAAs) have been found in a fraction of sera from patients with newly diagnosed insulin-dependent diabetes mellitus (IDDM) before onset of insulin treatment. Only sera lacking insulin antibodies have been analyzed, to avoid interference. Competitive inhibition studies provide specificity for human proinsulin but not for insulin. IgG-PAAs largely cross-react with human C-peptide. Precursors of insulin thus are involved in the immune process of IDDM.
Am Diabetes Assoc