Genetic and pathogenic basis of autoimmune diabetes in NOD mice
DV Serreze, EH Leiter - Current opinion in immunology, 1994 - Elsevier
DV Serreze, EH Leiter
Current opinion in immunology, 1994•ElsevierNon-obese diabetic (NOD) mice are an excellent model of T-cell mediated autoimmune
insulin-dependent diabetes in humans. Recent studies in NOD mice have shown that this
disease is a result of epistatic interactions between multiple genes, both inside and outside
the major histocompatibility complex (MHC), generating T cells reactive against an
expanding repertoire of autoantigens.
insulin-dependent diabetes in humans. Recent studies in NOD mice have shown that this
disease is a result of epistatic interactions between multiple genes, both inside and outside
the major histocompatibility complex (MHC), generating T cells reactive against an
expanding repertoire of autoantigens.
Abstract
Non-obese diabetic (NOD) mice are an excellent model of T-cell mediated autoimmune insulin-dependent diabetes in humans. Recent studies in NOD mice have shown that this disease is a result of epistatic interactions between multiple genes, both inside and outside the major histocompatibility complex (MHC), generating T cells reactive against an expanding repertoire of autoantigens.
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