Unscheduled DNA replication precedes apoptosis of photoreceptors expressing SV40 T antigen
MR Al-Ubaidi, NJ Mangini, AB Quiambao… - Experimental eye …, 1997 - Elsevier
Expression of simian virus 40 T antigen (Tag) in the rod photoreceptors of transgenic mice
leads to cell death that is completed by the end of the third week of postnatal development.
To understand the mechanistic link between Tag expression and the death of the expressing
photoreceptors, cell cycle activity was followed in a transgenic mouse family that expresses
Tag directed by the mouse opsin promoter. Tag-expressing photoreceptors also expressed
rhodopsin suggesting that these cells were differentiated. The presence of Tag in the …
leads to cell death that is completed by the end of the third week of postnatal development.
To understand the mechanistic link between Tag expression and the death of the expressing
photoreceptors, cell cycle activity was followed in a transgenic mouse family that expresses
Tag directed by the mouse opsin promoter. Tag-expressing photoreceptors also expressed
rhodopsin suggesting that these cells were differentiated. The presence of Tag in the …