[HTML][HTML] The cell-surface form of colony-stimulating factor-1 is regulated by osteotropic agents and supports formation of multinucleated osteoclast-like cells
GQ Yao, B Sun, EE Hammond, EN Spencer… - Journal of Biological …, 1998 - ASBMB
Colony-stimulating factor-1 (CSF-1) is a hematopoietic growth factor that is released by
osteoblasts and is recognized to play a critical role in bone remodeling in vivo and in vitro.
CSF-1 is synthesized as a soluble or cell-surface protein. It is unclear, however, whether
human osteoblasts express both molecular forms of CSF-1, and whether these isoforms can
independently mediate osteoclastogenesis. In the present study, using a combination of
quantitative reverse transcriptase polymerase chain reaction, flow cytometry, and Western …
osteoblasts and is recognized to play a critical role in bone remodeling in vivo and in vitro.
CSF-1 is synthesized as a soluble or cell-surface protein. It is unclear, however, whether
human osteoblasts express both molecular forms of CSF-1, and whether these isoforms can
independently mediate osteoclastogenesis. In the present study, using a combination of
quantitative reverse transcriptase polymerase chain reaction, flow cytometry, and Western …