[HTML][HTML] Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lepob/Lepob mice
Obesity is a common nutritional problem often associated with diabetes, insulin resistance,
and fatty liver (excess fat deposition in liver). Leptin-deficient Lep ob/Lep ob mice develop
obesity and those obesity-related syndromes. Increased lipogenesis in both liver and
adipose tissue of these mice has been suggested. We have previously shown that the
transcription factor sterol regulatory element-binding protein-1 (SREBP-1) plays a crucial
role in the regulation of lipogenesis in vivo. To explore the possible involvement of SREBP-1 …
and fatty liver (excess fat deposition in liver). Leptin-deficient Lep ob/Lep ob mice develop
obesity and those obesity-related syndromes. Increased lipogenesis in both liver and
adipose tissue of these mice has been suggested. We have previously shown that the
transcription factor sterol regulatory element-binding protein-1 (SREBP-1) plays a crucial
role in the regulation of lipogenesis in vivo. To explore the possible involvement of SREBP-1 …